MeV gamma-ray is a unique window for the direct measurement of line emissions from radioisotopes, but there is no significant progress in the observation after COMPTEL/{it CGRO}. Hence, for observing celestial objects in this band, we are developing an electron-tracking Compton camera (ETCC), which enables us to perform true imaging spectroscopy similar to X-ray or GeV telescopes. Therefore, we can obtain the energy spectrum of the observation target by a simple ON-OFF method using the correctly defined a proper point-spread function. For validating the performance of celestial object observation using an ETCC, the second balloon SMILE-2+, which had an ETCC based on a gaseous electron tracker with a volume of 30$times$30$times$30~cm$^3$, was launched at Alice Springs, Australia on April 7, 2018. SMILE-2+ observed the southern sky including the Crab nebula with a live time of 5.1 h at the zenith angle of $sim$50 degrees and detected gamma-rays from the Crab nebula with a significance of 4.0$sigma$ at the energy range of 0.15--2.1~MeV. Additionally, an enhancement of gamma-ray events due to the Galactic center region was clearly observed in the light curve. The realized detection sensitivity agrees well with the sensitivity estimated before launching based on the total background of extragalactic diffuse, atmospheric gamma-rays, and a small number of instrumental gamma-rays suppressed to one-third of the total background. We have succeeded to overcome the most difficult and serious problem of huge background for the stagnation of MeV gamma-ray astronomy for the first time in the world, and thus demonstrate that an ETCC can pioneer a deeper survey than COMPTEL in MeV gamma-ray astronomy.