Using $e^+e^-$ collision data at ten center-of-mass energies between 2.644 and 3.080 GeV collected with the BESIII detector at BEPCII and corresponding to an integrated luminosity of about 500 pb$^{-1}$, we measure the cross sections and effective form factors for the process $e^{+}e^{-}rightarrowXi^{0}bar{Xi}^{0}$ utilizing a single-tag method. A fit to the cross section of $e^{+}e^{-}rightarrowXi^{0}bar{Xi}^{0}$ with a pQCD-driven power function is performed, from which no significant resonance or threshold enhancement is observed. In addition, the ratio of cross sections for the processes $e^{+}e^{-}rightarrowXi^{-}bar{Xi}^{+}$ and $Xi^{0}bar{Xi}^{0}$ is calculated using recent BESIII measurement and is found to be compatible with expectation from isospin symmetry.