We develop a formalism for photoionization (PI) and potential energy curves (PECs) of Rydberg atoms in ponderomotive optical lattices and apply it to examples covering several regimes of the optical-lattice depth. The effect of lattice-induced PI on Rydberg-atom lifetime ranges from noticeable to highly dominant when compared with natural decay. The PI behavior is governed by the generally rapid decrease of the PI cross sections as a function of angular-momentum ($ell$), and by lattice-induced $ell$-mixing across the optical-lattice PECs. In GHz-deep lattices, $ell$-mixing leads to a rich PEC structure, and the significant low-$ell$ PI cross sections are distributed over many lattice-mixed Rydberg states. In lattices less than several tens-of-MHz deep, atoms on low-$ell$ PECs are essentially $ell$-mixing-free and maintain large PI cross sections, while atoms on high-$ell$ PECs trend towards being PI-free. Characterization of PI in GHz-deep Rydberg-atom lattices may be beneficial for optical control and quantum-state manipulation of Rydberg atoms, while data on PI in shallower lattices are potentially useful in high-precision spectroscopy and quantum-computing applications of lattice-confined Rydberg atoms.