The question whether global symmetries can be realized in quantum-gravity-matter-systems has far-reaching phenomenological consequences. Here, we collect evidence that within an asymptotically safe context, discrete global symmetries of the form $mathbb{Z}_n$, $n>4$, cannot be realized in a near-perturbative regime. In contrast, an effective-field-theory approach to quantum gravity might feature such symmetries, providing a mechanism to generate mass hierarchies in the infrared without the need for additional fine-tuning.