In order to investigate the role of gas in the demise of star formation on kpc-scales, we compare the resolved molecular gas main sequence (rMGMS: Sigma_* vs Sigma_H2) of star-forming regions to the sequence of `retired regions that have ceased to form new stars. Using data from the ALMaQUEST survey, we find that retired spaxels form a rMGMS that is distinct from that of star-forming spaxels, offset to lower Sigma_H2 at fixed Sigma_* by a factor of ~5. We study the rMGMS of star-forming and retired spaxels on a galaxy-by-galaxy basis for eight individual ALMaQUEST galaxies. Six of these galaxies have their retired spaxels concentrated within the central few kpc. Molecular gas is detected in 40-100% of retired spaxels in the eight galaxies in our sample. Both the star-forming and retired rMGMS show a diversity in normalization from galaxy-to-galaxy. However, in any given galaxy, the rMGMS for retired regions is found to be distinct from the star-forming sequence and gas fractions of retired spaxels are up to an order of magnitude lower than the star-forming spaxels. We conclude that quenching is associated with a depletion (but not absence) of molecular gas via a mechanism that typically begins in the centre of the galaxy.