Breast cancer screening is one of the most common radiological tasks with over 39 million exams performed each year. While breast cancer screening has been one of the most studied medical imaging applications of artificial intelligence, the development and evaluation of the algorithms are hindered due to the lack of well-annotated large-scale publicly available datasets. This is particularly an issue for digital breast tomosynthesis (DBT) which is a relatively new breast cancer screening modality. We have curated and made publicly available a large-scale dataset of digital breast tomosynthesis images. It contains 22,032 reconstructed DBT volumes belonging to 5,610 studies from 5,060 patients. This included four groups: (1) 5,129 normal studies, (2) 280 studies where additional imaging was needed but no biopsy was performed, (3) 112 benign biopsied studies, and (4) 89 studies with cancer. Our dataset included masses and architectural distortions which were annotated by two experienced radiologists. Additionally, we developed a single-phase deep learning detection model and tested it using our dataset to serve as a baseline for future research. Our model reached a sensitivity of 65% at 2 false positives per breast. Our large, diverse, and highly-curated dataset will facilitate development and evaluation of AI algorithms for breast cancer screening through providing data for training as well as common set of cases for model validation. The performance of the model developed in our study shows that the task remains challenging and will serve as a baseline for future model development.
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