Together with the rapid development of the Internet of Things (IoT), human activity recognition (HAR) using wearable Inertial Measurement Units (IMUs) becomes a promising technology for many research areas. Recently, deep learning-based methods pave a new way of understanding and performing analysis of the complex data in the HAR system. However, the performance of these methods is mostly based on the quality and quantity of the collected data. In this paper, we innovatively propose to build a large database based on virtual IMUs and then address technical issues by introducing a multiple-domain deep learning framework consisting of three technical parts. In the first part, we propose to learn the single-frame human activity from the noisy IMU data with hybrid convolutional neural networks (CNNs) in the semi-supervised form. For the second part, the extracted data features are fused according to the principle of uncertainty-aware consistency, which reduces the uncertainty by weighting the importance of the features. The transfer learning is performed in the last part based on the newly released Archive of Motion Capture as Surface Shapes (AMASS) dataset, containing abundant synthetic human poses, which enhances the variety and diversity of the training dataset and is beneficial for the process of training and feature transfer in the proposed method. The efficiency and effectiveness of the proposed method have been demonstrated in the real deep inertial poser (DIP) dataset. The experimental results show that the proposed methods can surprisingly converge within a few iterations and outperform all competing methods.