Understanding dynamics of localized quantum systems embedded in engineered bosonic environments is a central problem in quantum optics and open quantum system theory. We present a formalism for studying few-particle scattering from a localized quantum system interacting with an bosonic bath described by an inhomogeneous wave-equation. In particular, we provide exact relationships between the quantum scattering matrix of this interacting system and frequency domain solutions of the inhomogeneous wave-equation thus providing access to the spatial distribution of the scattered few-particle wave-packet. The formalism developed in this paper paves the way to computationally understanding the impact of structured media on the scattering properties of localized quantum systems embedded in them without simplifying assumptions on the physics of the structured media.