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We present local biplots, a an extension of the classic principal components biplot to multi-dimensional scaling. Noticing that principal components biplots have an interpretation as the Jacobian of a map from data space to the principal subspace, we define local biplots as the Jacobian of the analogous map for multi-dimensional scaling. In the process, we show a close relationship between our local biplot axes, generalized Euclidean distances, and generalized principal components. In simulations and real data we show how local biplots can shed light on what variables or combinations of variables are important for the low-dimensional embedding provided by multi-dimensional scaling. They give particular insight into a class of phylogenetically-informed distances commonly used in the analysis of microbiome data, showing that different variants of these distances can be interpreted as implicitly smoothing the data along the phylogenetic tree and that the extent of this smoothing is variable.
Mediation analysis has become an important tool in the behavioral sciences for investigating the role of intermediate variables that lie in the path between a randomized treatment and an outcome variable. The influence of the intermediate variable on
Tracking and estimating Daily Fine Particulate Matter (PM2.5) is very important as it has been shown that PM2.5 is directly related to mortality related to lungs, cardiovascular system, and stroke. That is, high values of PM2.5 constitute a public he
In microbiome studies, one of the ways of studying bacterial abundances is to estimate bacterial composition based on the sequencing read counts. Various transformations are then applied to such compositional data for downstream statistical analysis,
Modern microbiome compositional data are often high-dimensional and exhibit complex dependency among microbial taxa. However, existing approaches to analyzing microbiome compositional data either do not adequately account for the complex dependency o
Identifying which taxa in our microbiota are associated with traits of interest is important for advancing science and health. However, the identification is challenging because the measured vector of taxa counts (by amplicon sequencing) is compositi