Existences of vector-like quarks (VLQs) are predicted in many new physics scenarios beyond the Standard Model (SM). We study the possibility of detecting the vector-like bottom quark (VLQ-$B$) being the $SU(2)$ singlet with electric charge $-1/3$ at the Large Hadron Electron Collider (LHeC) in a model-independent framework. The decay properties and single production of VLQ-$B$ at the LHeC are explored. Three types of signatures are investigated. By carrying out a fast simulation for the signals and the corresponding backgrounds, the signal significances are obtained. Our numerical results show that detecting of VLQ-$B$ via the semileptonic channel is better than via the fully hadronic or leptonic channel.