Molecular communication (MC) allows nanomachines to communicate and cooperate with each other in a fluid environment. The diffusion-based MC is popular but is easily constrained by the transmit distance due to the severe attenuation of molecule concentrations. In this letter, we present a decode-and-forward (DF) relay strategy for the reversible binding receptor in the diffusion-based MC system. The time-varying spatial distribution of the information molecules based on the reversible association and dissociation between ligand and receptor at the surface of receiver is characterized. An analytical expression for the evaluation of expected error probability is derived, and the key factors impacting on the performance are exploited. Results show that with a constant molecular budget, the proposal can improve the performance significantly, and the performance gain can be enhanced by optimizing the position of the relay node and the number of molecules assigned to the source node.
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