We review a recently proposed phenomenological framework to establish the notions of QCD factorization and universality of jet cross sections in the heavy-ion environment. First results of a global analysis of the nuclear modification factor of inclusive jets are presented where we extract medium modified jet functions using a Monte Carlo sampling approach. We observe that gluon jets are significantly more suppressed than quark jets. In addition, we study the jet radius dependence of the inclusive jet cross section in heavy-ion collisions and comment on a recent measurement from CMS. By considering for example jet substructure observables it will be possible to test the universality of the extracted medium jet functions. We thus expect that the presented results will eventually allow for extractions of medium properties with a reduced model bias.