We extend the nonsupersymmetric SO(10) grand unification theories by adding a horizontal symmetry, which connects the three generations of fermions. Without committing to any specific symmetry group, we investigate the 1-loop renormalization group evolutions of the gauge couplings with one and two intermediate breaking scales. We find that depending on the SO(10) breaking chains, gauge coupling unification is compatible with only a handful of choices of representations of the Higgs bosons under the horizontal symmetry.
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