Renault proved in 2008 that if $G$ is a topologically principal groupoid, then $C_0(G^{(0)})$ is a Cartan subalgebra in $C^*_r(G, Sigma)$ for any twist $Sigma$ over $G$. However, there are many groupoids which are not topologically principal, yet their (twisted) $C^*$-algebras admit Cartan subalgebras. This paper gives a dynamical description of a class of such Cartan subalgebras, by identifying conditions on a 2-cocycle $c$ on $G$ and a subgroupoid $S subseteq G$ under which $C^*_r(S, c)$ is Cartan in $C^*_r(G, c)$. When $G$ is a discrete group, we also describe the Weyl groupoid and twist associated to these Cartan pairs, under mild additional hypotheses.
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