Characterizing high-dimensional entangled states is of crucial importance in quantum information science and technology. Recent theoretical progress has been made to extend the Hardys paradox into a general scenario with multisetting multidimensional systems, which can surpass the bound limited by the original version. Hitherto, no experimental verification has been conducted to verify such a Hardys paradox, as most of previous experimental efforts were restricted to two-dimensional systems. Here, based on two-photon high-dimensional orbital angular momentum (OAM) entanglement, we report the first experiment to demonstrate the Hardys paradox for multiple settings and multiple outcomes. We demonstrate the paradox for two-setting higher-dimensional OAM subspaces up to d = 7, which reveals that the nonlocal events increase with the dimension. Furthermore, we showcase the nonlocality with an experimentally recording probability of 36.77% for five-setting three-dimensional OAM subspace via entanglement concentration, and thus showing a sharper contradiction between quantum mechanics and classical theory.