Supertwistors relevant to $AdS_5times S^5$ superbackground of IIB supergravity are studied in the framework of the $D=10$ massless superparticle model in the first-order formulation. Product structure of the background suggests using $D=1+4$ Lorentz-harmonic variables to express momentum components tangent to $AdS_5$ and $D=5$ harmonics to express momentum components tangent to $S^5$ that yields eight-supertwistor formulation of the superparticles Lagrangian. We find incidence relations of the supertwistors with the $AdS_5times S^5$ superspace coordinates and the set of the quadratic constraints they satisfy. It is shown how using the constraints for the (Lorentz-)harmonic variables it is possible to reduce eight-supertwistor formulation to the four-supertwistor one. Respective supertwistors agree with those introduced previously in other models. Advantage of the four-supertwistor formulation is the presence only of the first-class constraints that facilitates analysis of the superparticle model.