Following the ideas of Ginzburg, for a subgroup $K$ of a connected reductive $mathbb{R}$-group $G$ we introduce the notion of $K$-admissible $D$-modules on a homogeneous $G$-variety $Z$. We show that $K$-admissible $D$-modules are regular holonomic when $K$ and $Z$ are absolutely spherical. This framework includes: (i) the relative characters attached to two spherical subgroups $H_1$ and $H_2$, provided that the twisting character $chi_i$ factors through the maximal reductive quotient of $H_i$, for $i = 1, 2$; (ii) localization on $Z$ of Harish-Chandra modules; (iii) the generalized matrix coefficients when $K(mathbb{R})$ is maximal compact. This complements the holonomicity proven by Aizenbud--Gourevitch--Minchenko. The use of regularity is illustrated by a crude estimate on the growth of $K$-admissible distributions which based on tools from subanalytic geometry.
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