Hemispherical power asymmetry has emerged as a new challenge to cosmology in early universe. While the cosmic microwave background (CMB) measurements indicated the asymmetry amplitude $A simeq 0.07$ at the CMB scale $k_{rm CMB}simeq 0.0045,{rm Mpc}^{-1}$, the high-redshift quasar observations found no significant deviation from statistical isotropy. This conflict can be reconciled in some scale-dependent asymmetry models. We put forward a new parameterization of scale-dependent asymmetric power spectrum, inspired by a multi-speed inflation model. The 21-cm power spectrum from the epoch of reionization can be used to constrain the scale-dependent hemispherical asymmetry. We demonstrate that an optimum, multi-frequency observation by the Square Kilometre Array (SKA) Phase 2 can impose a constraint on the amplitude of the power asymmetry anomaly at the level of $Delta A simeq 0.2$ at $0.056 lesssim k_{rm 21cm} lesssim 0.15 ,{rm Mpc}^{-1}$. This limit may be further improved by an order of magnitude as $Delta A simeq 0.01$ with a cosmic variance limited experiment such as the Omniscope.