Eigenvalue problems for linear differential equations, such as time-independent Schrodinger equations, can be generalized to eigenvalue problems for nonlinear differential equations. In the nonlinear context a separatrix plays the role of an eigenfunction and the initial conditions that give rise to the separatrix play the role of eigenvalues. Previously studied examples of nonlinear differential equations that possess discrete eigenvalue spectra are the first-order equation $y(x)=cos[pi xy(x)]$ and the first, second, and fourth Painleve transcendents. It is shown here that the differential equations for the first and second Painleve transcendents can be generalized to large classes of nonlinear differential equations, all of which have discrete eigenvalue spectra. The large-eigenvalue behavior is studied in detail, both analytically and numerically, and remarkable new features, such as hyperfine splitting of eigenvalues, are described quantitatively.