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Estimation of mutual information between (multidimensional) real-valued variables is used in analysis of complex systems, biological systems, and recently also quantum systems. This estimation is a hard problem, and universally good estimators provably do not exist. Kraskov et al. (PRE, 2004) introduced a successful mutual information estimation approach based on the statistics of distances between neighboring data points, which empirically works for a wide class of underlying probability distributions. Here we improve this estimator by (i) expanding its range of applicability, and by providing (ii) a self-consistent way of verifying the absence of bias, (iii) a method for estimation of its variance, and (iv) a criterion for choosing the values of the free parameter of the estimator. We demonstrate the performance of our estimator on synthetic data sets, as well as on neurophysiological and systems biology data sets.
Mutual Information (MI) plays an important role in representation learning. However, MI is unfortunately intractable in continuous and high-dimensional settings. Recent advances establish tractable and scalable MI estimators to discover useful repres
Background: Alignment of biological sequences such as DNA, RNA or proteins is one of the most widely used tools in computational bioscience. All existing alignment algorithms rely on heuristic scoring schemes based on biological expertise. Therefore,
Recent contrastive representation learning methods rely on estimating mutual information (MI) between multiple views of an underlying context. E.g., we can derive multiple views of a given image by applying data augmentation, or we can split a sequen
In this work, we introduce a new methodology for inferring the interaction structure of discrete valued time series which are Poisson distributed. While most related methods are premised on continuous state stochastic processes, in fact, discrete and
Mutual information is a widely-used information theoretic measure to quantify the amount of association between variables. It is used extensively in many applications such as image registration, diagnosis of failures in electrical machines, pattern r