The discovery of quadrupole topology opens a new horizon in the study of topological phenomena. However, the existing experimental realizations of quadrupole topological insulators in symmorphic lattices with $pi$-fluxes often break the protective mirror symmetry. Here, we present a theory for anomalous quadrupole topological insulators in nonsymmorphic crystals without flux, using 2D sonic crystals with $p4gm$ and $p2gg$ symmetry groups as concrete examples. We reveal that the anomalous quadrupole topology is protected by two orthogonal glide symmetries in square or rectangular lattices. The distinctive features of the anomalous quadrupole topological insulators include: (i) minimal four bands below the topological band gap, (ii) nondegenerate, gapped Wannier bands and special Wannier sectors with gapped composite Wannier bands, (iii) quantized Wannier band polarizations in these Wannier sectors. Remarkably, the protective glide symmetries are well-preserved in the sonic-crystal realizations where higher-order topological transitions can be triggered by symmetry or geometry engineering.
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