We establish n-th order Frechet differentiability with respect to the initial datum of mild solutions to a class of jump-diffusions in Hilbert spaces. In particular, the coefficients are Lipschitz continuous, but their derivatives of order higher than one can grow polynomially, and the (multiplicative) noise sources are a cylindrical Wiener process and a quasi-left-continuous integer-valued random measure. As preliminary steps, we prove well-posedness in the mild sense for this class of equations, as well as first-order G^ateaux differentiability of their solutions with respect to the initial datum, extending previous results in several ways. The differentiability results obtained here are a fundamental step to construct classical solutions to non-local Kolmogorov equations with sufficiently regular coefficients by probabilistic means.
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