The clinical management of several cardiovascular conditions, such as pulmonary hypertension, require the assessment of the right ventricular (RV) function. This work addresses the fully automatic and robust access to one of the key RV biomarkers, its ejection fraction, from the gold standard imaging modality, MRI. The problem becomes the accurate segmentation of the RV blood pool from cine MRI sequences. This work proposes a solution based on Fully Convolutional Neural Networks (FCNN), where our first contribution is the optimal combination of three concepts (the convolution Gated Recurrent Units (GRU), the Generative Adversarial Networks (GAN), and the L1 loss function) that achieves an improvement of 0.05 and 3.49 mm in Dice Index and Hausdorff Distance respectively with respect to the baseline FCNN. This improvement is then doubled by our second contribution, the ROI-GAN, that sets two GANs to cooperate working at two fields of view of the image, its full resolution and the region of interest (ROI). Our rationale here is to better guide the FCNN learning by combining global (full resolution) and local Region Of Interest (ROI) features. The study is conducted in a large in-house dataset of $sim$ 23.000 segmented MRI slices, and its generality is verified in a publicly available dataset.
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