Obtaining 3D information from a single X-ray exposure at high-brilliance sources, such as X-ray free-electron lasers (XFELs) [1] or diffraction-limited storage rings [2], allows the study of fast dynamical processes in their native environment. However, current X-ray 3D methodologies are either not compatible with single-shot approaches because they rely on multiple exposures, such as confocal microscopy [3, 4] and tomography [5, 6]; or they record a single projection per pulse [7] and are therefore restricted to approximately two-dimensional objects [8]. Here we propose and verify experimentally a novel imaging approach named X-ray multi-projection imaging (XMPI), which simultaneously acquires several projections without rotating the sample at significant tomographic angles. When implemented at high-brilliance sources it can provide volumetric information using a single pulse. Moreover, XMPI at MHz repetition XFELs could allow a way to record 3D movies of deterministic or stochastic natural processes in the micrometer to nanometer resolution range, and at time scales from microseconds down to femtoseconds.
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