Since the incident nuclei in heavy-ion collisions do not carry strangeness, the global net strangeness of the detected hadrons has to vanish. We investigate the impact of strangeness neutrality on the phase structure and thermodynamics of QCD at finite baryon and strangeness chemical potential. To this end, we study the low-energy sector of QCD within a Polyakov loop enhanced quark-meson effective theory with 2+1 dynamical quark flavors. Non-perturbative quantum, thermal, and density fluctuations are taken into account with the functional renormalization group. We show that the impact of strangeness neutrality on thermodynamic quantities such as the equation of state is sizable.
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