A novel technique using machine learning (ML) to reduce the computational cost of evaluating lattice quantum chromodynamics (QCD) observables is presented. The ML is trained on a subset of background gauge field configurations, called the labeled set, to predict an observable $O$ from the values of correlated, but less compute-intensive, observables $mathbf{X}$ calculated on the full sample. By using a second subset, also part of the labeled set, we estimate the bias in the result predicted by the trained ML algorithm. A reduction in the computational cost by about $7%-38%$ is demonstrated for two different lattice QCD calculations using the Boosted decision tree regression ML algorithm: (1) prediction of the nucleon three-point correlation functions that yield isovector charges from the two-point correlation functions, and (2) prediction of the phase acquired by the neutron mass when a small Charge-Parity (CP) violating interaction, the quark chromoelectric dipole moment interaction, is added to QCD, again from the two-point correlation functions calculated without CP violation.
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