We compute the leading order (LO) $qgto q gamma$ and next-to-leading order (NLO) $ggto q{bar q} gamma$ contributions to inclusive photon production in proton-proton (p+p) collisions at the LHC. These channels provide the dominant contribution at LO and NLO for photon transverse momenta $k_{gammaperp}$ corresponding to momentum fractions of $xleq 0.01$ in the colliding protons. Our computations, performed in the dilute-dense framework of the Color Glass Condensate effective field theory (CGC EFT), show that the NLO contribution dominates at small-$x$ because it is sensitive to $k_perp$-dependent unintegrated gluon distributions in both of the protons. We predict a maximal $10%$ modification of the cross section at low $k_{gammaperp}$ as a direct consequence of the violation of $k_perp$-factorization. The coherence effects responsible for this modification are enhanced in nuclei and can be identified from inclusive photon measurements in proton-nucleus collisions. We provide numerical results for the isolated inclusive photon cross section for $k_{gammaperp}leq 20$ GeV in p+p collisions that can be tested in the future at the LHC.
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