Consider a set of jobs with independent random service times to be scheduled on a single machine. The jobs can be surgeries in an operating room, patients appointments in outpatient clinics, etc. The challenge is to determine the optimal sequence and appointment times of jobs to minimize some function of the server idle time and service start-time delay. We introduce a generalized objective function of delay and idle time, and consider $l_1$-type and $l_2$-type cost functions as special cases of interest. Determining an index-based policy for the optimal sequence in which to schedule jobs has been an open problem for many years. For example, it was conjectured that `least variance first (LVF) policy is optimal for the $l_1$-type objective. This is known to be true for the case of two jobs with specific distributions. A key result in this paper is that the optimal sequencing problem is non-indexable, i.e., neither the variance, nor any other such index can be used to determine the optimal sequence in which to schedule jobs for $l_1$ and $l_2$-type objectives. We then show that given a sequence in which to schedule the jobs, sample average approximation yields a solution which is statistically consistent.
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