Using a turn-key Ti:sapphire femtosecond laser frequency comb, an off-the-shelf supercontinuum device, and Fabry-Perot mode filters, we report the generation of a 16 GHz frequency comb spanning a 90 nm band about a center wavelength of 566 nm. The light from this astro-comb is used to calibrate the HARPS-N astrophysical spectrograph for precision radial velocity measurements. The comb-calibrated spectrograph achieves a stability of $sim$ 1 cm/s within half an hour of averaging time. We also use the astro-comb as a reference for measurements of solar spectra obtained with a compact telescope, and as a tool to study intrapixel sensitivity variations on the CCD of the spectrograph.