Very recently, the CMS collaboration has reported a search for the production for a Standard Model (SM) Higgs boson in association with a top quark pair ($t bar{t} H$) at the LHC Run-2 and a best fit $t bar{t} H$ yield of $1.5 pm 0.5$ times the SM prediction with an observed significance of $3.3 sigma$. We study a possibility of whether or not this observed deviation can be explained by anomalous Higgs Yukawa couplings with the top and the bottom quarks, along with the LHC Run-1 data for the Higgs boson properties. We find that anomalous top and bottom Yukawa couplings with about $0-20$% and $10-40$% reductions from their SM values, respectively, can simultaneously fit the recent CMS result and the LHC Run-1 data.