We introduce and discuss notions of regularity and flexibility for Lagrangian manifolds with Legendrian boundary in Weinstein domains. There is a surprising abundance of flexible Lagrangians. In turn, this leads to new constructions of Legendrians submanifolds and Weinstein manifolds. For instance, many closed $n$-manifolds of dimension $n>2$ can be realized as exact Lagrangian submanifolds of $T^*S^n$ with possibly exotic Weinstein symplectic structures. These Weinstein structures on $T^* S^n$, infinitely many of which are distinct, are formed by a single handle attachment to the standard $2n$-ball along the Legendrian boundaries of flexible Lagrangians. We also formulate a number of open problems.
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