We consider estimating the parameter associated with the qubit depolarizing channel when the available initial states that might be employed are mixed. We use quantum Fisher information as a measure of the accuracy of estimation to compare protocols which use collections of qubits in product states to one in which the qubits are in a correlated state. We show that, for certain parameter values and initial states, the correlated state protocol can yield a greater accuracy per channel invocation than the product state protocols. We show that, for some parameters and initial states, using more than two qubits and channel invocations is advantageous. These results stand in contrast to the known optimal case that uses pure initial states and a single channel invocation on a pair of entangled qubits.
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