In this paper, we employ a nonlocal $Q$-curvature flow inspired by Gursky-Malchiodis work cite{gur_mal} to solve the prescribed $Q$-curvature problem on a class of closed manifolds: For $n geq 5$, let $(M^n,g_0)$ be a smooth closed manifold, which is not conformally diffeomorphic to the standard sphere, satisfying either Gursky-Malchiodis semipositivity hypotheses: scalar curvature $R_{g_0}>0$ and $Q_{g_0} geq 0$ not identically zero or Hang-Yangs: Yamabe constant $Y(g_0)>0$, Paneitz-Sobolev constant $q(g_0)>0$ and $Q_{g_0} geq 0$ not identically zero. Let $f$ be a smooth positive function on $M^n$ and $x_0$ be some maximum point of $f$. Suppose either (a) $n=5,6,7$ or $(M^n,g_0)$ is locally conformally flat; or (b) $n geq 8$, Weyl tensor at $x_0$ is nonzero. In addition, assume all partial derivatives of $f$ vanish at $x_0$ up to order $n-4$, then there exists a conformal metric $g$ of $g_0$ with its $Q$-curvature $Q_g$ equal to $f$. This result generalizes Escobar-Schoens work [Invent. Math. 1986] on prescribed scalar curvature problem on any locally conformally flat manifolds of positive scalar curvature.
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