First observations of the rare decays $B^+rightarrow K^+pi^+pi^-mu^+mu^-$ and $B^+rightarrow phi K^+mu^+mu^-$ are presented using data corresponding to an integrated luminosity of $3.0,{fb}^{-1}$, collected by the LHCb experiment at centre-of-mass energies of $7$ and $8mathrm{,TeV}$. The branching fractions of the decays are begin{eqnarray*} mathcal{B}(B^+rightarrow K^+pi^+pi^-mu^+mu^-) &=& (4.36,^{+0.29}_{-0.27},mathrm{(stat)}pm 0.21,mathrm{(syst)}pm0.18,mathrm{(norm)})times10^{-7}, mathcal{B}(B^+rightarrowphi K^+mu^+mu^-) &=& (0.82 ,^{+0.19}_{-0.17},mathrm{(stat)},^{+0.10}_{-0.04},mathrm{(syst)}pm0.27,mathrm{(norm)}) times10^{-7},end{eqnarray*} where the uncertainties are statistical, systematic, and due to the uncertainty on the branching fractions of the normalisation modes. A measurement of the differential branching fraction in bins of the invariant mass squared of the dimuon system is also presented for the decay $B^+rightarrow K^+pi^+pi^-mu^{+}mu^{-}$.