We investigate the colour-magnitude relation of metal-poor globular clusters, the blue tilt, in the Hydra and Centaurus galaxy clusters and constrain the primordial conditions for star cluster self-enrichment. We analyse U,I photometry for about 2500 globular clusters in the central regions of Hydra and Centaurus, based on FORS1@VLT data. We convert the measured colour-magnitude relations into mass-metallicity space and obtain a scaling of Z propto M^{0.27 pm 0.05} for Centaurus GCs and Z propto M^{0.40 pm 0.06} for Hydra GCs, consistent with results in other environments. We find that the GC mass-metallicity relation already sets in at present-day masses of a few 10^5 solar masses and is well established in the luminosity range of massive MW clusters like omega Centauri. We compare the mass-metallicity relation with predictions from the star cluster self-enrichment model by Bailin & Harris (2009). For this we include effects of dynamical and stellar evolution and a physically well motivated primordial mass-radius scaling. The self-enrichment model reproduces the observed relations well for average primordial half-light radii r_h ~ 1-1.5 pc, star formation efficiencies f_* ~ 0.3-0.4, and pre-enrichment levels of [Fe/H] ~ -1.7 dex. Within the self-enrichment scenario, the observed blue tilt implies a correlation between GC mass and width of the stellar metallicity distribution. We find that this implied correlation matches the trend of width with GC mass measured in Galactic GCs, including extreme cases like omega Cen and M54. We conclude that 1. A primordial star cluster mass-radius relation provides a significant improvement to the self-enrichment model fits. 2. Broadenend metallicity distributions as found in some massive MW globular clusters may have arisen naturally from self-enrichment processes, without the need of a dwarf galaxy progenitor.