Symbiotic stars display absorption lines of a cool red giant together with emission lines of a nebula ionized by a hotter star, indicative of an active binary star system in which mass transfer is occurring. PIONIER at the VLT has been used to combine the light of four telescopes at a time to study in unprecedented detail how mass is transferred in symbiotic stars. The results of a mini-survey of symbiotic stars with PIONIER are summarised and some tentative general results about the role of Roche lobe overflow are presented.