We investigate how to experimentally detect a recently proposed measure to quantify macroscopic quantum superpositions [Phys. Rev. Lett. 106, 220401 (2011)], namely, macroscopic quantumness $mathcal{I}$. Schemes based on overlap measurements for harmonic oscillator states and for qubit states are extensively investigated. Effects of detection inefficiency and coarse-graining are analyzed in order to assess feasibility of the schemes.