The discovery of acceleration and dark energy arguably constitutes the most revolutionary discovery in astrophysics in recent years. Cerro Tololo Inter-American Observatory (CTIO) played a key role in this amazing discovery through three systematic supernova surveys organized by staff astronomers: the Tololo Supernova Program (1986-2000), the Calan/Tololo Project (1989-1993), and the High-Z Supernova Search Team (1994-1998). CTIOs state of the art instruments also were fundamental in the independent discovery of acceleration by the Supernova Cosmology Project (1992-1999). Here I summarize the work on supernovae carried out from CTIO that led to the discovery of acceleration and dark energy and provide a brief historical summary on the use of Type Ia supernovae in cosmology in order to provide context for the CTIO contribution.