The van der Waals interaction between a lipid membrane and a substrate covered by a graphene sheet is investigated using the Lifshitz theory. The reflection coefficients are obtained for a layered planar system submerged in water. The dielectric response properties of the involved materials are also specified and discussed. Our calculations show that a graphene covered substrate can repel the biological membrane in water. This is attributed to the significant changes in the response properties of the system due to the monolayer graphene. It is also found that the van der Waals interaction is mostly dominated by the presence of graphene, while the role of the particular substrate is secondary.