Our ability to resolve new physics effects is, largely, limited by the precision with which we calculate. The calculation of observables in the Standard (or a new physics) Model requires knowledge of associated hadronic contributions. The precision of such calculations, and therefore our ability to leverage experiment, is typically limited by hadronic uncertainties. The only first-principles method for calculating the nonperturbative, hadronic contributions is lattice QCD. Modern lattice calculations have controlled errors, are systematically improvable, and in some cases, are pushing the sub-percent level of precision. I outline the role played by, highlight state of the art efforts in, and discuss possible future directions of lattice calculations in flavor physics.