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تسجيل مستخدم جديدPrecision and reproducibility of macroscopic developmental patterns
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Developmental processes in multicellular organisms occur far from equilibrium, yet produce complex patterns with astonishing reproducibility. We measure the precision and reproducibility of bilaterally symmetric fly wings across the natural range of genetic and environmental conditions and find that wing patterns are specified with identical spatial precision and are reproducible to within a single cell width. The early fly embryo operates at a similar degree of reproducibility, suggesting that the overall spatial precision of morphogenesis in Drosophila performs at the single cell level, arguably the physical limit of what a biological system can achieve.
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Cell fate decisions in multicellular organisms are precisely coordinated, leading to highly reproducible macroscopic outcomes of developmental processes. The origins of this reproducibility can be found at the molecular level during the earliest stag
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