The quasiparticle interference (QPI) in Sr$_{2}$RuO$_{4}$ is theoretically studied based on two different pairing models in order to propose an experimental method to test them. For a recently proposed two-dimensional model with pairing primarily from the $gamma$ band, we found clear QPI peaks evolving with energy and their locations can be determined from the tips of the constant-energy contour (CEC). On the other hand, for a former quasi-one-dimensional model with pairing on the $alpha$ and $beta$ bands, the QPI spectra are almost dispersionless and may involve off-shell contributions to the scatterings beyond the CEC. The different behaviors of the QPI in these two models may help to resolve the controversy of active/passive bands and whether Sr$_{2}$RuO$_{4}$ is a topological superconductor.