We present a set of hydro-dynamical numerical simulations of the Antennae galaxies in order to understand the origin of the central overlap starburst. Our dynamical model provides a good match to the observed nuclear and overlap star formation, especially when using a range of rather inefficient stellar feedback efficiencies (0.01 < q_EoS < 0.1). In this case a simple conversion of local star formation to molecular hydrogen surface density motivated by observations accounts well for the observed distribution of CO. Using radiative transfer post-processing we model synthetic far-infrared spectral energy distributions (SEDs) and two-dimensional emission maps for direct comparison with Herschel-PACS observations. For a gas-to-dust ratio of 62:1 and the best matching range of stellar feedback efficiencies the synthetic far-infrared SEDs of the central star forming region peak at values of ~65 - 81 Jy at 99 - 116 um, similar to a three-component modified black body fit to infrared observations. Also the spatial distribution of the far-infrared emission at 70 um, 100 um, and 160 um compares well with the observations: >50% (> 35%) of the emission in each band is concentrated in the overlap region while only < 30% (< 15%) is distributed to the combined emission from the two galactic nuclei in the simulations (observations). As a proof of principle we show that parameter variations in the feedback model result in unambiguous changes both in the global and in the spatially resolved observable far-infrared properties of Antennae galaxy models. Our results strengthen the importance of direct, spatially resolved comparative studies of matched galaxy merger simulations as a valuable tool to constrain the fundamental star formation and feedback physics.