We consider the prospects for measuring the pairwise kinetic Sunyaev-Zeldovich (kSZ) signal from galaxy clusters discovered in large photometric surveys such as the Dark Energy Survey (DES). We project that the DES cluster sample will, in conjunction with existing mm-wave data from the South Pole Telescope (SPT), yield a detection of the pairwise kSZ signal at the 8-13 sigma level, with sensitivity peaking for clusters separated by ~100 Mpc distances. A next-generation version of SPT would allow for a 18-30 sigma detection and would be limited by variance from the kSZ signal itself and residual thermal Sunyaev-Zeldovich (tSZ) signal. Throughout our analysis we assume photometric redshift errors, which wash out the signal for clusters separated by <~50 Mpc; a spectroscopic survey of the DES sample would recover this signal and allow for a 26-43 sigma detection, and would again be limited by kSZ/tSZ variance. Assuming a standard model of structure formation, these high-precision measurements of the pairwise kSZ signal will yield detailed information on the gas content of the galaxy clusters. Alternatively, if the gas can be sufficiently characterized by other means (e.g. using tSZ, X-ray, or weak lensing), then the relative velocities of the galaxy clusters can be isolated, thereby providing a precision measurement of gravity on 100 Mpc scales. We briefly consider the utility of these measurements for constraining theories of modified gravity.