With the increasing number of Quad-Core-based clusters and the introduction of compute nodes designed with large memory capacity shared by multiple cores, new problems related to scalability arise. In this paper, we analyze the overall performance of a cluster built with nodes having a dual Quad-Core Processor on each node. Some benchmark results are presented and some observations are mentioned when handling such processors on a benchmark test. A Quad-Core-based clusters complexity arises from the fact that both local communication and network communications between the running processes need to be addressed. The potentials of an MPI-OpenMP approach are pinpointed because of its reduced communication overhead. At the end, we come to a conclusion that an MPI-OpenMP solution should be considered in such clusters since optimizing network communications between nodes is as important as optimizing local communications between processors in a multi-core cluster.