ﻻ يوجد ملخص باللغة العربية
Detection and characterization of individual nano-scale particles, virions, and pathogens are of paramount importance to human health, homeland security, diagnostic and environmental monitoring[1]. There is a strong demand for high-resolution, portable, and cost-effective systems to make label-free detection and measurement of individual nanoparticles, molecules, and viruses [2-6]. Here, we report an easily accessible, real-time and label-free detection method with single nanoparticle resolution that surpasses detection limit of existing micro- and nano-photonic devices. This is achieved by using an ultra-narrow linewidth whispering gallery microlaser, whose lasing line undergoes frequency splitting upon the binding of individual nano-objects. We demonstrate detection of polystyrene and gold nanoparticles as small as 15 nm and 10 nm in radius, respectively, and Influenza A virions by monitoring changes in self-heterodyning beat note of the split lasing modes. Experiments are performed in both air and aqueous environment. The built-in self-heterodyne interferometric method achieved in a microlaser provides a self-reference scheme with extraordinary sensitivity [7,8], and paves the way for detection and spectroscopy of nano-scale objects using micro- and nano-lasers.
Whispering gallery mode biosensors allow selective unlabelled detection of single proteins and, combined with quantum limited sensitivity, the possibility for noninvasive realtime observation of motor molecule motion. However, to date technical noise
Recently optical whispering-gallery-mode resonators (WGMRs) have emerged as promising platforms to achieve label-free detection of nanoscale objects and to reach single molecule sensitivity. The ultimate detection performance of WGMRs are limited by
We have demonstrated a 165 micron oblate spheroidal microcavity with free spectral range 383.7 GHz (3.06nm), resonance bandwidth 25 MHz (Q ~ 10^7) at 1550nm, and finesse F > 10^4. The highly oblate spheroidal dielectric microcavity combines very high
We investigate numerically and experimentally the statistics of the changes in the amount of frequency splitting upon the adsorption of particles one-by-one into the mode volume of whispering gallery mode (WGM) microresonator and microlasers. This mu
We review our recent work on tunable, ultrahigh quality factor whispering-gallery-mode bottle microresonators and highlight their applications in nonlinear optics and in quantum optics experiments. Our resonators combine ultra-high quality factors of