We review the main advances brought by the Spitzer Space Telescope in the field of nearby galaxies studies, concentrating on a few subject areas, including: (1) the physics of the Polycyclic Aromatic Hydrocarbons that generate the mid-infrared features between ~3.5 micron and ~20 micron; (2) the use of the mid- and far-infrared emission from galaxies as star formation rate indicators; and (3) the improvement of mid-infrared diagnostics to discriminate between thermal (star-formation) and non-thermal (AGN) emission in galaxies and galaxy centers.
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