The Cosmic Ray Energetics And Mass (CREAM) calorimeter is designed to measure the spectra of cosmic-ray particles over the energy range from ~10^11 eV to ~10^15 eV. Its first flight as part of the CREAM-I balloon-borne payload in Antarctica during the 2004/05 season resulted in a recordbreaking 42 days of exposure. Calorimeter calibration using various beam test data will be discussed in an attempt to assess the uncertainties of the energy measurements.