Let $p$ be a prime. Let $(R,ideal{m})$ be a regular local ring of mixed characteristic $(0,p)$ and absolute index of ramification $e$. We provide general criteria of when each abelian scheme over $Spec Rsetminus{ideal{m}}$ extends to an abelian scheme over $Spec R$. We show that such extensions always exist if $ele p-1$, exist in most cases if $ple ele 2p-3$, and do not exist in general if $ege 2p-2$. The case $ele p-1$ implies the uniqueness of integral canonical models of Shimura varieties over a discrete valuation ring $O$ of mixed characteristic $(0,p)$ and index of ramification at most $p-1$. This leads to large classes of examples of Neron models over $O$. If $p>2$ and index $p-1$, the examples are new.