In this review, we discuss some interesting issues in charm physics which is full with puzzles and challenges. So far in the field there exist many problems which have not obtained satisfactory answers yet and more unexpected phenomena have been observed at the present facilities of high energy physics. Charm physics may become an ideal place for searching new resonances and studying non-perturbative QCD effects, moreover probably is an area to explore new physics beyond the Standard Model. More data will be available at BESIII, B-factories, LHC and even future ILC which may open a wide window to a better understanding of the nature.